(Carbethoxymethylene)triphenylphosphorane

• CAT Number: R009722
• CAS Number: 1099-45-2
• Molecular Formula: C22H21O2P
• Molecular Weight: 348.38
• Purity: ≥95%
• Synonyms: 2-(Triphenylphosphoranylidene)acetic Acid Ethyl Ester; (2-Ethoxy-2-oxoethylidene)triphenylphosphorane; Ethyl (triphenylphosphoranylidene)acetate; NSC 72406
• Storage: -20°C
• IUPAC Name: ethyl 2-(triphenyl-$l^{5}
• InChI: InChI=1S/C22H21O2P/c1-2-24-22(23)18-25(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h3-18H,2H2,1H3
• InChIKey: IIHPVYJPDKJYOU-UHFFFAOYSA-N
• SMILES: CCOC(=O)C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

(Carbethoxymethylene)triphenylphosphorane(CAT: R009722) is a stabilized Wittig reagent commonly used in organic synthesis for the formation of α,β-unsaturated esters via olefination reactions. Featuring a phosphonium ylide structure with a carbethoxy (ethyl ester) functional group, it enables the selective conversion of aldehydes and ketones into trans-configured α,β-unsaturated compounds. This reagent is especially valuable in constructing carbon–carbon double bonds with high regio- and stereocontrol. It is widely used in the synthesis of complex natural products, pharmaceuticals, and intermediates for fine chemicals. Its bench-stable nature and reliable reactivity make it a key tool in advanced synthetic and medicinal chemistry research.