Calpain-2-IN-1

• CAT Number: I044159
• CAS Number: 144231-85-6
• Molecular Formula: C28H37N3O7
• Molecular Weight: 527.61
• Purity: ≥95%
• Synonyms: benzyl N-[(2S)-1-[[(3S)-1-[(3,5-dimethoxyphenyl)methylamino]-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
• InChI: InChI=1S/C28H37N3O7/c1-6-23(25(32)27(34)29-16-20-13-21(36-4)15-22(14-20)37-5)30-26(33)24(12-18(2)3)31-28(35)38-17-19-10-8-7-9-11-19/h7-11,13-15,18,23-24H,6,12,16-17H2,1-5H3,(H,29,34)(H,30,33)(H,31,35)/t23-,24-/m0/s1
• InChIKey: ZPKXXXUPXHNDFV-ZEQRLZLVSA-N
• SMILES: CC[C@@H](C(=O)C(=O)NCC1=CC(=CC(=C1)OC)OC)NC(=O)[C@H](CC(C)C)NC(=O)OCC2=CC=CC=C2

Calpain-2-IN-1（Cat No.:I044159）is a selective small-molecule inhibitor of calpain-2, a calcium-dependent cysteine protease involved in cellular processes such as cytoskeletal remodeling, cell motility, apoptosis, and signal transduction. Overactivation of calpain-2 is implicated in various pathological conditions, including neurodegeneration, cancer progression, and cardiovascular diseases. Calpain-2-IN-1 inhibits proteolytic activity by targeting the active site of the enzyme, thereby preventing the cleavage of calpain substrates. It is widely used in preclinical research to study calpain-2-specific functions and to explore therapeutic potential in diseases where aberrant calpain-2 activity contributes to tissue damage or tumor invasiveness.