For research use only. Not for therapeutic Use.
Calhex 231 hydrochloride（Cat No.:I015591）is a potent negative allosteric modulator of the calcium-sensing receptor (CaSR), which regulates extracellular calcium homeostasis and parathyroid hormone (PTH) secretion. By inhibiting CaSR activity, Calhex 231 enhances PTH release, making it a useful tool in studying calcium metabolism, parathyroid function, and bone remodeling. Supplied as a hydrochloride salt, it provides stability and solubility for laboratory use. This compound has been applied in endocrine and metabolic research to explore therapeutic approaches for hypocalcemia, osteoporosis, and disorders linked to dysregulated CaSR signaling.
| CAS Number | 2387505-78-2 |
| Synonyms | 4-chloro-N-[(1S,2S)-2-[[(1R)-1-naphthalen-1-ylethyl]amino]cyclohexyl]benzamide;hydrochloride |
| Molecular Formula | C25H28Cl2N2O |
| Purity | ≥95% |
| IUPAC Name | 4-chloro-N-[(1S,2S)-2-[[(1R)-1-naphthalen-1-ylethyl]amino]cyclohexyl]benzamide;hydrochloride |
| InChI | InChI=1S/C25H27ClN2O.ClH/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)27-23-11-4-5-12-24(23)28-25(29)19-13-15-20(26)16-14-19;/h2-3,6-10,13-17,23-24,27H,4-5,11-12H2,1H3,(H,28,29);1H/t17-,23+,24+;/m1./s1 |
| InChIKey | KZPHZSFSFANQIS-GRFVZBLOSA-N |
| SMILES | C[C@H](C1=CC=CC2=CC=CC=C21)N[C@H]3CCCC[C@@H]3NC(=O)C4=CC=C(C=C4)Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
