Calcitonin Gene Related Peptide (CGRP) II, rat TFA

• CAT Number: I046114
• Molecular Formula: C163H267N51O50S2.xC2HF3O2
• Molecular Weight: 3805.31 (free base)
• Purity: ≥95%
• IUPAC Name: (3S)-4-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(4R,7S,10S,13S,16S,19R)-19-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-16-(2-amino-2-oxoethyl)-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C163H267N51O50S2.C2HF3O2/c1-73(2)51-97(186-116(227)64-179-130(233)81(17)183-139(242)98(52-74(3)4)193-137(240)94(43-34-48-176-162(171)172)188-142(245)101(56-90-61-175-72-182-90)199-159(262)128(87(23)222)213-156(259)123(79(13)14)207-151(254)110-71-266-265-70-109(203-133(236)91(166)66-215)150(253)197-103(58-113(168)224)147(250)211-125(84(20)219)157(260)185-83(19)132(235)210-126(85(21)220)160(263)204-110)140(243)194-99(53-75(5)6)141(244)202-108(69-218)149(252)190-95(44-35-49-177-163(173)174)138(241)201-106(67-216)134(237)180-62-115(226)178-63-118(229)205-121(77(9)10)155(258)208-122(78(11)12)154(257)191-93(42-31-33-47-165)136(239)198-105(60-119(230)231)144(247)196-102(57-112(167)223)143(246)195-100(55-89-39-28-25-29-40-89)145(248)209-124(80(15)16)161(264)214-50-36-45-111(214)152(255)212-127(86(22)221)158(261)200-104(59-114(169)225)146(249)206-120(76(7)8)153(256)181-65-117(228)187-107(68-217)148(251)189-92(41-30-32-46-164)135(238)184-82(18)131(234)192-96(129(170)232)54-88-37-26-24-27-38-88;3-2(4,5)1(6)7/h24-29,37-40,61,72-87,91-111,120-128,215-222H,30-36,41-60,62-71,164-166H2,1-23H3,(H2,167,223)(H2,168,224)(H2,169,225)(H2,170,232)(H,175,182)(H,178,226)(H,179,233)(H,180,237)(H,181,256)(H,183,242)(H,184,238)(H,185,260)(H,186,227)(H,187,228)(H,188,245)(H,189,251)(H,190,252)(H,191,257)(H,192,234)(H,193,240)(H,194,243)(H,195,246)(H,196,247)(H,197,253)(H,198,239)(H,199,262)(H,200,261)(H,201,241)(H,202,244)(H,203,236)(H,204,263)(H,205,229)(H,206,249)(H,207,254)(H,208,258)(H,209,248)(H,210,235)(H,211,250)(H,212,255)(H,213,259)(H,230,231)(H4,171,172,176)(H4,173,174,177);(H,6,7)/t81-,82-,83-,84+,85+,86+,87+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-;/m0./s1
• InChIKey: HCQYCJWEBKBRAU-BCJPXGLLSA-N
• SMILES: C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)[C@@H](C)O)CC(=O)N)NC(=O)[C@H](CO)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N)[C@@H](C)O.C(=O)(C(F)(F)F)O

Calcitonin Gene Related Peptide (CGRP) II, rat TFA（Cat No.:I046114）, is a synthetic peptide analog of the rat neuropeptide CGRP II, supplied as its trifluoroacetate salt. CGRP is a potent vasodilatory neuropeptide involved in pain transmission, neurogenic inflammation, and cardiovascular regulation. The rat CGRP II sequence is widely used in preclinical neuroscience and cardiovascular studies to explore migraine pathophysiology, sensory neurotransmission, and vascular tone modulation. As a research tool, this peptide supports investigations into CGRP receptor interactions, signal transduction, and the development of therapeutic agents targeting migraine and vascular disorders.