For research use only. Not for therapeutic Use.
Caffeoyltryptophan(CAT: I040431) is a bioactive conjugate of caffeic acid and tryptophan that functions as a competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting an IC₅₀ of 16.99 μM. Inhibiting PTP1B, a negative regulator of insulin signaling, makes it a promising candidate for type 2 diabetes research. Additionally, Caffeoyltryptophan demonstrates inhibitory effects on α-glucosidase, linoleic acid peroxidation, and red blood cell haemolysis, indicating antioxidant and antidiabetic potential. This multifunctional compound is suitable for metabolic disorder studies, particularly in exploring novel therapeutic strategies targeting insulin resistance, glucose metabolism, and oxidative stress. Ideal for drug discovery and nutraceutical development in diabetes management.
| CAS Number | 109163-69-1 |
| Synonyms | (2S)-2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-3-(1H-indol-3-yl)propanoic acid |
| Molecular Formula | C20H18N2O5 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-3-(1H-indol-3-yl)propanoic acid |
| InChI | InChI=1S/C20H18N2O5/c23-17-7-5-12(9-18(17)24)6-8-19(25)22-16(20(26)27)10-13-11-21-15-4-2-1-3-14(13)15/h1-9,11,16,21,23-24H,10H2,(H,22,25)(H,26,27)/b8-6+/t16-/m0/s1 |
| InChIKey | XITPERBRJNUFSB-BVBGJJFLSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)C=CC3=CC(=C(C=C3)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
