For research use only. Not for therapeutic Use.
C12-200（Cat No.:I045137）is a synthetic lipid-like compound (lipidoid) developed for efficient delivery of nucleic acids, particularly small interfering RNA (siRNA) and messenger RNA (mRNA). As a key component in lipid nanoparticle (LNP) formulations, C12-200 facilitates cellular uptake and endosomal escape, enabling effective intracellular delivery of genetic cargo. It features a 12-carbon alkyl tail and ionizable amine groups, allowing it to form stable complexes with negatively charged nucleic acids. C12-200 has demonstrated high transfection efficiency and low toxicity in preclinical models. Supplied for research in RNA therapeutics, gene delivery, and nanomedicine development.
| CAS Number | 1220890-25-4 |
| Synonyms | 1-[2-[bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol |
| Molecular Formula | C70H145N5O5 |
| Purity | ≥95% |
| IUPAC Name | 1-[2-[bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol |
| InChI | InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3 |
| InChIKey | RVHYPUORVDKRTM-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCC(CN(CCN1CCN(CC1)CCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
