c-Kit-IN-5-1

• CAT Number: I021961
• CAS Number: 1003311-62-3
• Molecular Formula: C23H17N5O2
• Molecular Weight: 395.41
• Purity: ≥95%
• Synonyms: 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one
• InChI: InChI=1S/C23H17N5O2/c1-14-8-10-28(18-5-2-15(3-6-18)21-25-9-11-30-21)22(29)20(14)16-4-7-19-17(12-16)13-26-23(24)27-19/h2-13H,1H3,(H2,24,26,27)
• InChIKey: IGFSMGCBFTXTJK-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)C3=NC=CO3)C4=CC5=CN=C(N=C5C=C4)N

c-Kit-IN-5-1（Cat No.:I021961）is a potent and selective inhibitor of c-Kit (CD117), a receptor tyrosine kinase involved in cell proliferation, survival, and differentiation, particularly in hematopoietic stem cells, melanocytes, and germ cells. By blocking c-Kit signaling, c-Kit-IN-5-1 disrupts downstream pathways such as PI3K/AKT and MAPK, making it a valuable tool in cancer research, especially for gastrointestinal stromal tumors (GISTs), mastocytosis, and leukemia. This compound helps elucidate c-Kit’s role in oncogenesis and therapeutic resistance. c-Kit-IN-5-1 is intended for laboratory research use only and is not suitable for clinical or veterinary applications.