For research use only. Not for therapeutic Use.
BX430(CAT: I011238) is a potent, selective, and noncompetitive allosteric antagonist of the human P2X4 receptor channel, with an IC₅₀ of 0.54 μM. It demonstrates strong species specificity, effectively inhibiting human and zebrafish P2X4 while showing no activity on rat or mouse orthologs. BX430 exhibits negligible impact on other P2X subtypes (P2X1–P2X3, P2X5, P2X7) even at concentrations 10–100× above its IC₅₀. In human P2X4-expressing cells, BX430 significantly reduces ATP-evoked intracellular calcium responses, including thapsigargin-induced calcium rises. Widely used in chronic pain and cardiovascular research, BX430 is a valuable tool for dissecting P2X4-mediated signaling pathways.
| CAS Number | 688309-70-8 |
| Synonyms | 1-(2,6-dibromo-4-propan-2-ylphenyl)-3-pyridin-3-ylurea |
| Molecular Formula | C15H15Br2N3O |
| Purity | ≥95% |
| IUPAC Name | 1-(2,6-dibromo-4-propan-2-ylphenyl)-3-pyridin-3-ylurea |
| InChI | InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21) |
| InChIKey | JFNKIJKRXKPQCC-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC(=C(C(=C1)Br)NC(=O)NC2=CN=CC=C2)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
