For research use only. Not for therapeutic Use.
BTK inhibitor 10(CAT: I017137) is a potent and orally active Bruton’s tyrosine kinase (BTK) inhibitor, reported in patent WO2018145525 (Example 33). It has demonstrated strong therapeutic potential for rheumatoid arthritis by modulating B-cell receptor signaling pathways that drive inflammation and autoimmune progression. In a collagen-induced arthritis (CIA) mouse model, oral administration at 30 mg/kg once daily for 21 days significantly improved clinical symptoms, reducing the mean arthritic score to 3.62 compared with 8.33 in controls. With its efficacy and oral bioavailability, BTK inhibitor 10 represents a valuable candidate for research into autoimmune diseases and inflammatory disorders.
| CAS Number | 2241732-30-7 |
| Synonyms | N-[3-[[6-(4-morpholin-4-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide |
| Molecular Formula | C25H23N5O3 |
| Purity | ≥95% |
| IUPAC Name | N-[3-[[6-(4-morpholin-4-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide |
| InChI | InChI=1S/C25H23N5O3/c1-2-23(31)28-18-4-3-5-20(14-18)33-25-21-15-22(29-24(21)26-16-27-25)17-6-8-19(9-7-17)30-10-12-32-13-11-30/h2-9,14-16H,1,10-13H2,(H,28,31)(H,26,27,29) |
| InChIKey | KLSYFSMLPFKXDQ-UHFFFAOYSA-N |
| SMILES | C=CC(=O)NC1=CC(=CC=C1)OC2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)N5CCOCC5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
