For research use only. Not for therapeutic Use.
BT44 (Cat No.: I041303) is a small molecule mimetic of glial cell line-derived neurotrophic factor (GDNF), developed to activate the RET receptor signaling pathway involved in neuronal survival and regeneration. It crosses the blood-brain barrier and has shown neuroprotective effects in models of Parkinson’s disease and other neurodegenerative disorders. By stimulating GDNF-like activity without requiring the native protein, BT44 offers a promising therapeutic strategy for CNS diseases. It is widely studied for its potential in promoting neuronal health and functional recovery.
| CAS Number | 924759-42-2 |
| Synonyms | [4-[5-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)-2-methoxyphenyl]piperazin-1-yl]-[4-fluoro-2-(trifluoromethyl)phenyl]methanone |
| Molecular Formula | C28H27F4N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C28H27F4N3O4S/c1-39-26-9-7-22(40(37,38)35-11-10-19-4-2-3-5-20(19)18-35)17-25(26)33-12-14-34(15-13-33)27(36)23-8-6-21(29)16-24(23)28(30,31)32/h2-9,16-17H,10-15,18H2,1H3 |
| InChIKey | MFQBJWVTKPJNEP-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)S(=O)(=O)N2CCC3=CC=CC=C3C2)N4CCN(CC4)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F |
| Reference | [1]. Viisanen H, et al. Novel RET agonist for the treatment of experimental neuropathies. Mol Pain. 2020 Jan-Dec;16:1744806920950866. [2]. Renko JM, et al. Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats. J Parkinsons Dis. 2021;11(3):1023-1046. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
