BSJ-4-116

• CAT Number: I044455
• CAS Number: 2519823-34-6
• Molecular Formula: C40H49ClN8O8S
• Molecular Weight: 837.38
• Purity: ≥95%
• Synonyms: N-[7-[(3R)-3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]piperidin-1-yl]heptyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
• InChI: InChI=1S/C40H49ClN8O8S/c1-25(2)58(55,56)32-16-7-6-14-29(32)45-36-28(41)22-43-40(47-36)44-26-12-11-21-48(23-26)20-9-5-3-4-8-19-42-34(51)24-57-31-15-10-13-27-35(31)39(54)49(38(27)53)30-17-18-33(50)46-37(30)52/h6-7,10,13-16,22,25-26,30H,3-5,8-9,11-12,17-21,23-24H2,1-2H3,(H,42,51)(H,46,50,52)(H2,43,44,45,47)/t26-,30?/m1/s1
• InChIKey: YJOJMGTVKMABKQ-FIQOPJFZSA-N
• SMILES: CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)N[C@@H]3CCCN(C3)CCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O

BSJ-4-116（Cat No.:I044455）is a selective, potent PROTAC (proteolysis-targeting chimera) degrader of BRD4 (bromodomain-containing protein 4), a member of the BET (bromodomain and extraterminal domain) family involved in transcriptional regulation of oncogenes like MYC. By recruiting BRD4 to an E3 ubiquitin ligase, BSJ-4-116 induces its ubiquitination and subsequent proteasomal degradation, leading to suppression of cancer cell proliferation and survival. It offers advantages over traditional BET inhibitors by promoting sustained protein depletion rather than reversible inhibition. BSJ-4-116 is a valuable tool for studying BET protein function and developing targeted therapies in oncology.