For research use only. Not for therapeutic Use.
BSJ-01-175（Cat No.:I045186）is a potent, selective, cereblon (CRBN)-recruiting PROTAC degrader designed to target cyclin-dependent kinase 6 (CDK6) for ubiquitination and proteasomal degradation. By harnessing CRBN-mediated E3 ligase activity, BSJ-01-175 efficiently reduces CDK6 protein levels, thereby inhibiting cell cycle progression and suppressing proliferation in CDK6-dependent cancers. It shows strong selectivity over CDK4, minimizing off-target effects. BSJ-01-175 is a valuable chemical biology tool for studying targeted protein degradation, CDK6-driven oncogenesis, and PROTAC design principles, with potential therapeutic relevance in hematologic malignancies and other CDK6-associated proliferative disorders.
| CAS Number | 2227392-55-2 |
| Synonyms | (E)-N-[4-[(1R,3R)-3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide |
| Molecular Formula | C30H33ClN6O2 |
| Purity | ≥95% |
| IUPAC Name | (E)-N-[4-[(1R,3R)-3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide |
| InChI | InChI=1S/C30H33ClN6O2/c1-37(2)16-6-11-28(38)34-20-12-14-22(15-13-20)39-23-8-5-7-21(17-23)35-30-33-19-26(31)29(36-30)25-18-32-27-10-4-3-9-24(25)27/h3-4,6,9-15,18-19,21,23,32H,5,7-8,16-17H2,1-2H3,(H,34,38)(H,33,35,36)/b11-6+/t21-,23-/m1/s1 |
| InChIKey | DMUSMYYDKCXFKR-MRJIRHQNSA-N |
| SMILES | CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)O[C@@H]2CCC[C@H](C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
