For research use only. Not for therapeutic Use.
Bryostatin 1(Cat No.:M020085)is a potent macrocyclic lactone derived from the marine organism Bugula neritina, known for its ability to activate protein kinase C (PKC). This compound has demonstrated potential in cancer treatment, particularly in enhancing the efficacy of chemotherapy and immunotherapy by modulating cell signaling pathways and promoting apoptosis in tumor cells. Additionally, bryostatin 1 shows promise in neurological research, as it may aid in synaptic plasticity and neuroprotection, offering potential therapeutic benefits in conditions like Alzheimer’s disease. Its unique mechanism of action makes it a valuable candidate for further therapeutic exploration.
Catalog Number | M020085 |
CAS Number | 83314-01-6 |
Synonyms | BRYOSTATIN 1;BRYO 1;2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3. |
Molecular Formula | C47H68O17 |
Purity | ≥95% |
Target | PKC |
Solubility | Soluble in DMSO > 10 mM |
Storage | Store at -20°C |
IUPAC Name | [(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate |
InChI | InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1 |
InChIKey | MJQUEDHRCUIRLF-TVIXENOKSA-N |
SMILES | CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/C[C@@H](O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O |
Reference | 1: Making Bryostatin 1 through Smart Chemistry. Cancer Discov. 2017 Oct 24. doi: 2: Wender PA, Hardman CT, Ho S, Jeffreys MS, Maclaren JK, Quiroz RV, Ryckbosch 3: López-Huertas MR, Jiménez-Tormo L, Madrid-Elena N, Gutiérrez C, Rodríguez-Mora 4: Alkon DL, Hongpaisan J, Sun MK. Effects of chronic bryostatin-1 on 5: Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. HIV-1 Latency-Reversing 6: Mizutani K, Sonoda S, Wakita H, Okazaki H, Katoh Y, Chihara T, Shimpo K. <br> |