Bromotripyrrolidinophosphonium Hexafluorophosphate

• CAT Number: R029658
• CAS Number: 132705-51-2
• Molecular Formula: C12H24BrF6N3P2
• Molecular Weight: 466.19
• Purity: ≥95%
• Synonyms: (T-4)-Bromotri-1-pyrrolidinyl-phosphorus(1+) Hexafluorophosphate(1-); Pyrrolidine Phosphorus Complex; Bromotris(pyrrolidino)phosphonium Hexafluorophosphate;?PyBroP
• Storage: Store at -20°C
• IUPAC Name: bromo(tripyrrolidin-1-yl)phosphanium;hexafluorophosphate
• InChI: InChI=1S/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1
• InChIKey: CYKRMWNZYOIJCH-UHFFFAOYSA-N
• SMILES: C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)Br.F[P-](F)(F)(F)(F)F

Bromotripyrrolidinophosphonium hexafluorophosphate (Cat No.:R029658) is a highly efficient coupling reagent used in peptide synthesis and organic chemistry. It contains a phosphonium core substituted with three pyrrolidine rings and a bromide moiety, paired with a hexafluorophosphate counterion. PyBroP is particularly valued for activating carboxylic acids to form amide bonds with minimal racemization, making it ideal for synthesizing peptides and other bioactive molecules. Its high reactivity and solubility in organic solvents allow for fast, efficient coupling under mild conditions. PyBroP is widely used in both solution-phase and solid-phase synthesis workflows.