Bromoacetamido-PEG4-NHS ester

• CAT Number: I016453
• CAS Number: 1260139-70-5
• Molecular Formula: C17H27BrN2O9
• Molecular Weight: 483.31
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C17H27BrN2O9/c18-13-14(21)19-4-6-26-8-10-28-12-11-27-9-7-25-5-3-17(24)29-20-15(22)1-2-16(20)23/h1-13H2,(H,19,21)
• InChIKey: BONNYNBXMCRXBJ-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC(=O)CBr

Bromoacetamido-PEG4-NHS ester(CAT: I016453) is a heterobifunctional crosslinker designed for efficient bioconjugation and protein labeling. It contains an NHS ester group, which reacts selectively with primary amines on lysine residues or N-termini, and a bromoacetamide group, which covalently modifies thiols on cysteine residues through alkylation. The PEG4 spacer enhances aqueous solubility, improves molecular flexibility, and minimizes steric hindrance, enabling stable and site-specific conjugation of biomolecules. This reagent is widely applied in antibody-drug conjugates (ADCs), protein–protein interaction studies, and surface functionalization. Bromoacetamido-PEG4-NHS ester provides a versatile tool for constructing multifunctional probes, drug delivery systems, and biomaterials with high precision.