Bromoacetamido-PEG2-C2-acid

• CAT Number: I016459
• CAS Number: 1415800-44-0
• Molecular Formula: C9H16BrNO5
• Molecular Weight: 298.13
• Purity: ≥95%
• Synonyms: 3-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C9H16BrNO5/c10-7-8(12)11-2-4-16-6-5-15-3-1-9(13)14/h1-7H2,(H,11,12)(H,13,14)
• InChIKey: PIANHFIJCGRNCU-UHFFFAOYSA-N
• SMILES: C(COCCOCCNC(=O)CBr)C(=O)O

Bromoacetamido-PEG2-C2-acid(CAT: I016459) is a heterobifunctional crosslinking reagent designed for thiol-specific and carboxyl-directed conjugation strategies. It contains a bromoacetamide group, which selectively alkylates free thiols on cysteine residues, and a terminal carboxylic acid, allowing further activation (e.g., EDC/NHS chemistry) for coupling to primary amines. The PEG2-C2 spacer improves solubility, minimizes steric hindrance, and provides molecular flexibility for efficient bioconjugation. This reagent is widely employed in protein labeling, antibody–drug conjugates (ADCs), surface modification, and biomaterials engineering. Bromoacetamido-PEG2-C2-acid enables stable and site-specific linkage formation, making it a versatile tool in chemical biology, drug delivery research, and nanotechnology applications.