Bromo-PEG2-MS

• CAT Number: I045415
• CAS Number: 1935075-34-5
• Molecular Formula: C5H11BrO4S
• Molecular Weight: 247.11
• Purity: ≥95%
• Synonyms: 2-(2-bromoethoxy)ethyl methanesulfonate
• InChI: InChI=1S/C5H11BrO4S/c1-11(7,8)10-5-4-9-3-2-6/h2-5H2,1H3
• InChIKey: DADINSRJAJTRQY-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCOCCBr

Bromo-PEG2-MS (Cat No.: I045415) is a bifunctional polyethylene glycol (PEG) linker consisting of two ethylene glycol units that provide flexibility and hydrophilicity. It features a terminal bromide group for nucleophilic substitution reactions and a methanesulfonate (mesylate, MS) group for efficient leaving group chemistry, enabling sequential or selective functionalization. The short PEG2 spacer reduces steric hindrance while improving solubility in both aqueous and organic media. This reagent is commonly employed in bioconjugation, surface modification, polymer synthesis, and the preparation of multifunctional molecules in chemical and biomedical research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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