Bromo-PEG1-C2-azide

• CAT Number: I015795
• CAS Number: 1144106-65-9
• Molecular Formula: C₄H₈BrN₃O
• Molecular Weight: 194.03
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 1-azido-2-(2-bromoethoxy)ethane
• InChI: InChI=1S/C4H8BrN3O/c5-1-3-9-4-2-7-8-6/h1-4H2
• InChIKey: SBVSTNMRZMYOGF-UHFFFAOYSA-N
• SMILES: C(COCCBr)N=[N+]=[N-]

Bromo-PEG1-C2-azide (Cat.No:I015795) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562