Brivudine

• CAT Number: R032315
• CAS Number: 69304-47-8
• Molecular Formula: C₁₁H₁₃BrN₂O₅
• Molecular Weight: 333.14
• Purity: ≥95%
• Storage: Store at RT

Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro.

Reference

1:Comparison of Famciclovir, Valaciclovir, and Brivudine Treatments in Adult Immunocompetent Patients With Herpes Zoster. Yaldiz M, Solak B, Kara RO, Cosansu N, Erdem MT.Am J Ther. 2016 Jan 20. [Epub ahead of print] PMID: 26808358 2:Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Hew K, Dahlroth SL, Veerappan S, Pan LX, Cornvik T, Nordlund P.PLoS One. 2015 Dec 2;10(12):e0143947. doi: 10.1371/journal.pone.0143947. eCollection 2015. PMID: 26630264 Free PMC Article3:Brivudine induced coronary vasospasm as a manifestation of Kounis syndrome: First report. Buturak A, Norgaz T, Gorgulu S.Int J Cardiol. 2015 Apr 15;185:4-6. doi: 10.1016/j.ijcard.2015.03.082. Epub 2015 Mar 10. No abstract available. PMID: 25777280 4:[Non-fatal drug-drug interaction between capecitabine and brivudine]. Baena Cañada JM, Martínez-Bautista MJ, Cortés-Carmona C, González-Carrascosa Vega T.Farm Hosp. 2013 Jul-Aug;37(4):342-3. doi: 10.7399/FH.2013.37.4.694. Spanish. No abstract available. PMID: 24010699 Free Article5:[Fatal drug-drug interaction between 5-fluorouracil and brivudine]. García Fernández V, Garrido Arévalo M, Labrada González E, Hidalgo Correas FJ.Farm Hosp. 2013 Jan-Feb;37(1):72-3. doi: 10.7399/FH.2013.37.1.271. Spanish. No abstract available. PMID: 23461503 Free Article6:Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine. Zhang NQ, Zhao L, Ma S, Gu M, Zheng XY.Asian Pac J Cancer Prev. 2012;13(5):2121-7. PMID: 22901180 Free Article7:RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients. Heinrich JC, Tuukkanen A, Schroeder M, Fahrig T, Fahrig R.J Cancer Res Clin Oncol. 2011 Sep;137(9):1349-61. doi: 10.1007/s00432-011-1005-1. Epub 2011 Jul 22. PMID: 21833720 8:Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet. Bleymehl K, Cinatl J, Schmidt-Chanasit J.Med Microbiol Immunol. 2011 Aug;200(3):193-202. doi: 10.1007/s00430-011-0191-4. Epub 2011 Mar 4. Erratum in: Med Microbiol Immunol. 2012 Aug;201(3):403-5. PMID: 21373931 9:Epstein-Barr virus encephalitis after kidney transplantation and successful treatment with brivudine. Lahmer T, Hoffmann D, Heemann U, Küchle C, Frank H.Transpl Int. 2010 Jun;23(6):e24-5. doi: 10.1111/j.1432-2277.2009.01045.x. Epub 2010 Jan 12. No abstract available. PMID: 20070626 Free Article10:Fatal drug-drug interaction of brivudine and capecitabine. Rätz Bravo AE, Hofer S, Krähenbühl S, Ludwig C.Acta Oncol. 2009;48(4):631-3. doi: 10.1080/02841860802660502. No abstract available. PMID: 19165642