BRD9757

• CAT Number: I012759
• CAS Number: 1423058-85-8
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.14
• Purity: ≥95%
• Synonyms: N-hydroxycyclopentene-1-carboxamide
• InChI: InChI=1S/C6H9NO2/c8-6(7-9)5-3-1-2-4-5/h3,9H,1-2,4H2,(H,7,8)
• InChIKey: RYYGSXXWQSXKRP-UHFFFAOYSA-N
• SMILES: C1CC=C(C1)C(=O)NO

BRD9757 (Cat No.: I012759) is a selective small molecule inhibitor of the histone deacetylase 6 (HDAC6) enzyme, involved in the regulation of protein degradation, cell motility, and stress responses. By inhibiting HDAC6, BRD9757 disrupts aggresome formation and enhances acetylation of α-tubulin and heat shock protein 90, promoting apoptosis in cancer cells. It is widely used in epigenetics and oncology research to explore non-histone deacetylation pathways. BRD9757 serves as a valuable tool for studying HDAC6-targeted therapeutic strategies in cancer and neurodegenerative diseases.

Reference

[1]. Florence F Wagner, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013 Feb 28;56(4):1772-6.
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