For research use only. Not for therapeutic Use.
BRD7389(CAT: I010881) is a selective RSK family kinase inhibitor with IC50 values of 1.5 μM (RSK1), 2.4 μM (RSK2), and 1.2 μM (RSK3). Beyond kinase inhibition, it acts as a small-molecule inducer of insulin expression in pancreatic α-cells. Treatment with BRD7389 (0.425–6.8 μM) for 3–5 days upregulates Ins2 mRNA in a dose-dependent manner, with ~50-fold induction at 0.85 μM after 5 days. It also increases Pdx1 mRNA in mouse α-cells and enhances β-cell–specific gene expression in primary human islet cells. Additionally, BRD7389 (1 μM) abolishes carbachol-induced proliferation, making it a valuable tool for diabetes and metabolic disease research.
| CAS Number | 376382-11-5 |
| Synonyms | 16-(2-phenylethylamino)-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-8,15-dione |
| Molecular Formula | C24H18N2O2 |
| Purity | ≥95% |
| IUPAC Name | 16-(2-phenylethylamino)-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-8,15-dione |
| InChI | InChI=1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28) |
| InChIKey | XASCINRGTHLHGM-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCNC2=C3C4=CC=CC=C4C(=O)C5=C3C(=CC=C5)NC2=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
