For research use only. Not for therapeutic Use.
BRD32048（Cat No.:R065291）is a cell-permeable small molecule that directly and reversibly binds to the ETS transcription factor ETV1 with a dissociation constant (K_D) of 17.1 µM . By inhibiting p300-dependent acetylation at lysines 33 and 116, BRD32048 promotes ETV1 degradation, thereby reducing its transcriptional activity . This modulation suppresses the invasion of ETV1-driven cancer cells, such as those in prostate cancer and melanoma . As a substituted [1,3,5]triazine derivative, BRD32048 serves as a valuable tool in studying ETV1-related oncogenic pathways and exploring targeted cancer therapies .
| CAS Number | 433694-46-3 |
| Synonyms | 2-N-(4-methoxyphenyl)-6-(piperidin-1-ylmethyl)-1,3,5-triazine-2,4-diamine |
| Molecular Formula | C16H22N6O |
| Purity | ≥95% |
| IUPAC Name | 2-N-(4-methoxyphenyl)-6-(piperidin-1-ylmethyl)-1,3,5-triazine-2,4-diamine |
| InChI | InChI=1S/C16H22N6O/c1-23-13-7-5-12(6-8-13)18-16-20-14(19-15(17)21-16)11-22-9-3-2-4-10-22/h5-8H,2-4,9-11H2,1H3,(H3,17,18,19,20,21) |
| InChIKey | PVHJDJWPRZUURH-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)NC2=NC(=NC(=N2)N)CN3CCCCC3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
