For research use only. Not for therapeutic Use.
Bractoppin（Cat No.:I023650）is a small-molecule inhibitor that specifically targets the BRCA1 tandem BRCT (BRCA1 C-terminal) domain, which is essential for BRCA1’s role in DNA damage response and repair via homologous recombination. By disrupting the BRCT-phosphopeptide interaction, Bractoppin impairs BRCA1’s recruitment to DNA double-strand breaks, thereby sensitizing cancer cells to DNA-damaging agents. It has shown potential as a chemosensitizer in BRCA1-proficient tumors, offering a novel therapeutic approach for overcoming resistance in cancer treatment. Bractoppin is an important tool compound in the study of BRCA1-mediated genome maintenance mechanisms.
| CAS Number | 2290527-07-8 |
| Synonyms | [4-[(2-fluorophenyl)methyl]piperazin-1-yl]-(2-phenyl-3H-benzimidazol-5-yl)methanone |
| Molecular Formula | C25H23FN4O |
| Purity | ≥95% |
| IUPAC Name | [4-[(2-fluorophenyl)methyl]piperazin-1-yl]-(2-phenyl-3H-benzimidazol-5-yl)methanone |
| InChI | InChI=1S/C25H23FN4O/c26-21-9-5-4-8-20(21)17-29-12-14-30(15-13-29)25(31)19-10-11-22-23(16-19)28-24(27-22)18-6-2-1-3-7-18/h1-11,16H,12-15,17H2,(H,27,28) |
| InChIKey | UHDGSNOZRAAGIZ-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC2=CC=CC=C2F)C(=O)C3=CC4=C(C=C3)N=C(N4)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
