Braco-19

• CAT Number: I015342
• CAS Number: 351351-75-2
• Molecular Formula: C35H43N7O2
• Molecular Weight: 593.76
• Purity: ≥95%
• Synonyms: N-[9-[4-(dimethylamino)anilino]-6-(3-pyrrolidin-1-ylpropanoylamino)acridin-3-yl]-3-pyrrolidin-1-ylpropanamide
• InChI: InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
• InChIKey: RKPYSYRMIXRZJT-UHFFFAOYSA-N
• SMILES: CN(C)C1=CC=C(C=C1)NC2=C3C=CC(=CC3=NC4=C2C=CC(=C4)NC(=O)CCN5CCCC5)NC(=O)CCN6CCCC6

BRACO-19（Cat No.:I015342）is a small-molecule ligand that stabilizes G-quadruplex DNA structures, thereby interfering with telomere maintenance and function. By binding to guanine-rich sequences at chromosome ends, it inhibits the activity of telomerase, an enzyme crucial for cancer cell immortality. This disruption leads to telomere dysfunction, genomic instability, and apoptosis in tumor cells. BRACO-19 has been widely studied as an anticancer agent, particularly in models of solid tumors and hematological malignancies. It serves as a valuable tool in cancer research, exploring telomere biology and therapeutic targeting of telomerase.