BPTF-IN-BZ1

• CAT Number: I045339
• CAS Number: 2766623-38-3
• Molecular Formula: C13H15ClN4O
• Molecular Weight: 278.74
• Purity: ≥95%
• Synonyms: 5-[4-(2-aminoethyl)anilino]-4-chloro-2-methylpyridazin-3-one
• InChI: InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
• InChIKey: UOQAFGWMKNIVAR-UHFFFAOYSA-N
• SMILES: CN1C(=O)C(=C(C=N1)NC2=CC=C(C=C2)CCN)Cl

BPTF‑IN‑BZ1 (Cat No.: I045339) is a pyridazinone‑based inhibitor targeting the bromodomain of BPTF (bromodomain PHD‑finger transcription factor), a chromatin reader involved in epigenetic regulation. With a binding affinity of Kd ≈ 6.3 nM, it displays >350‑fold selectivity over BET bromodomains, enabling precise modulation of BPTF function in cell‑based models. It is typically solubilized in DMSO and employed in vitro to explore gene regulation and BPTF‑dependent oncogenic pathways.

Reference

[1]. Zahid H, et al. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J Med Chem. 2021 Sep 23;64(18):13902-13917.
[Content Brief]