BPN-15606

• CAT Number: I017974
• CAS Number: 1914989-49-3
• Molecular Formula: C23H23FN6O
• Molecular Weight: 418.47
• Purity: ≥95%
• Synonyms: N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-4-methylpyridazin-3-amine
• IUPAC Name: N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methylimidazol-1-yl)-2-pyridinyl]-4-methylpyridazin-3-amine
• InChI: InChI=1S/C23H23FN6O/c1-14-11-20(28-29-22(14)26-16(3)17-5-7-18(24)8-6-17)19-9-10-21(23(27-19)31-4)30-12-15(2)25-13-30/h5-13,16H,1-4H3,(H,26,29)/t16-/m0/s1
• InChIKey: JZCREVMHGYOLRL-INIZCTEOSA-N
• SMILES: CC1=CC(=NN=C1N[C@@H](C)C2=CC=C(C=C2)F)C3=NC(=C(C=C3)N4C=C(N=C4)C)OC

BPN-15606（Cat No.:I017974）is a potent, brain-penetrant γ-secretase modulator (GSM) developed for the treatment of Alzheimer’s disease. Unlike γ-secretase inhibitors, it selectively lowers the production of the pathogenic amyloid-β42 peptide while sparing essential substrates such as Notch, reducing toxicity risks. In preclinical studies, BPN-15606 effectively reduced amyloid plaque burden and improved cognitive outcomes in Alzheimer’s models. With favorable pharmacokinetics and oral bioavailability, it represents a promising candidate for disease-modifying therapy. BPN-15606 is a valuable tool for research on amyloid biology and neurodegenerative disease mechanisms.