For research use only. Not for therapeutic Use.
BPK-25（Cat No.:I045264）is a selective inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation via phosphorylation of RNA polymerase II’s C-terminal domain. By blocking CDK9 activity, BPK-25 suppresses expression of genes with short-lived transcripts, including oncogenes such as MYC and MCL-1, leading to impaired cancer cell survival. This compound has shown potential in preclinical studies targeting transcriptional addiction in hematologic malignancies and certain solid tumors. Its potency, selectivity, and cellular activity make BPK-25 a valuable research tool for studying transcription regulation and developing CDK9-targeted anticancer strategies.
| CAS Number | 2305052-86-0 |
| Synonyms | 5-[(6-chloropyridin-2-yl)methyl-prop-2-enoylamino]-N-phenylpyridine-2-carboxamide |
| Molecular Formula | C21H17ClN4O2 |
| Purity | ≥95% |
| IUPAC Name | 5-[(6-chloropyridin-2-yl)methyl-prop-2-enoylamino]-N-phenylpyridine-2-carboxamide |
| InChI | InChI=1S/C21H17ClN4O2/c1-2-20(27)26(14-16-9-6-10-19(22)24-16)17-11-12-18(23-13-17)21(28)25-15-7-4-3-5-8-15/h2-13H,1,14H2,(H,25,28) |
| InChIKey | MHPBTJANPDDCPH-UHFFFAOYSA-N |
| SMILES | C=CC(=O)N(CC1=NC(=CC=C1)Cl)C2=CN=C(C=C2)C(=O)NC3=CC=CC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
