BPI-9016M

• CAT Number: I017232
• CAS Number: 1528546-94-2
• Molecular Formula: C25H18F2N4O3
• Molecular Weight: 460.43
• Purity: ≥95%
• Synonyms: N-[4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
• InChI: InChI=1S/C25H18F2N4O3/c26-15-3-1-14(2-4-15)18-12-28-13-19(23(18)32)25(33)31-16-5-6-22(20(27)11-16)34-21-8-10-30-24-17(21)7-9-29-24/h1-6,8,10-13H,7,9H2,(H,28,32)(H,29,30)(H,31,33)
• InChIKey: DGMFNZXEGKFREH-UHFFFAOYSA-N
• SMILES: C1CNC2=NC=CC(=C21)OC3=C(C=C(C=C3)NC(=O)C4=CNC=C(C4=O)C5=CC=C(C=C5)F)F

BPI-90169M(CAT: I017232) is a potent, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It effectively suppresses tumor cell growth, migration, and invasion in lung adenocarcinoma models. In vitro, BPI-9016M inhibits proliferation (IC₅₀: 5.3–27.1 μM across A549, H1299, H1650, H1975, HCC827, PC-9, and primary lung adenocarcinoma cells), induces G1 phase arrest, and reduces expression of c-Met, p-c-Met, p-AKT, and p-ERK in a dose-dependent manner. In vivo, oral administration (60 mg/kg daily) significantly restrains tumor growth in PDX xenograft NOD/SCID mouse models, highlighting its strong therapeutic potential for targeted lung cancer therapy.