BPH-652

For research use only. Not for therapeutic Use.

  • CAT Number: I004822
  • CAS Number: 157124-84-0
  • Molecular Formula: C16H16K3O7PS
  • Molecular Weight: 500.63
  • Purity: ≥95%
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BPH-652(CAT: I004822) is a potent inhibitor of Staphylococcus aureus dehydrosqualene synthase (CrtM), blocking staphyloxanthin biosynthesis and impairing bacterial virulence. It exhibits a Ki of 1.5 nM and an IC50 of 100–300 nM in pigment formation assays. In a murine infection model, intraperitoneal BPH-652 (0.5 mg twice daily, days −1 to 2) significantly reduced bacterial burden in kidneys compared with controls (P < 0.001), with 8 of 13 animals falling below detection versus 2 of 14 in controls, corresponding to a 98% average reduction. BPH-652 supports research into antivirulence therapies targeting carotenoid biosynthesis in S. aureus.


CAS Number 157124-84-0
Synonyms

tripotassium;4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonate

Molecular Formula C16H16K3O7PS
Purity ≥95%
IUPAC Name tripotassium;4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonate
InChI InChI=1S/C16H19O7PS.3K/c17-24(18,19)16(25(20,21)22)11-5-7-13-6-4-10-15(12-13)23-14-8-2-1-3-9-14;;;/h1-4,6,8-10,12,16H,5,7,11H2,(H2,17,18,19)(H,20,21,22);;;/q;3*+1/p-3
InChIKey DRADVLDMPYYQDB-UHFFFAOYSA-K
SMILES C1=CC=C(C=C1)OC2=CC=CC(=C2)CCCC(P(=O)([O-])[O-])S(=O)(=O)[O-].[K+].[K+].[K+]
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