BOS-318

• CAT Number: I043518
• CAS Number: 2387633-15-8
• Molecular Formula: C28H32Cl2N6O3
• Molecular Weight: 571.50
• Purity: ≥95%
• Synonyms: 2-[1-[[2-(3,5-dichlorophenyl)-6-[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxypyridin-4-yl]methyl]piperidin-4-yl]acetic acid
• InChI: InChI=1S/C28H32Cl2N6O3/c1-34-6-8-36(9-7-34)28-31-16-24(17-32-28)39-26-11-20(18-35-4-2-19(3-5-35)12-27(37)38)10-25(33-26)21-13-22(29)15-23(30)14-21/h10-11,13-17,19H,2-9,12,18H2,1H3,(H,37,38)
• InChIKey: AZEJIKZNBHEXCM-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=NC=C(C=N2)OC3=CC(=CC(=N3)C4=CC(=CC(=C4)Cl)Cl)CN5CCC(CC5)CC(=O)O

BOS-318（Cat No.:I043518）is a selective inhibitor of the enzyme BRAF, a key regulator of the MAPK/ERK signaling pathway, which is involved in cell growth and survival. Mutations in the BRAF gene, particularly BRAF V600E, are commonly associated with various cancers, including melanoma, colorectal cancer, and non-small cell lung cancer. By inhibiting BRAF, BOS-318 blocks aberrant cell signaling, leading to reduced tumor growth and improved response to cancer treatments. It is being investigated as a potential targeted therapy for patients with BRAF-driven cancers, offering a promising approach for more effective cancer treatment.