BOC-PNA-G(Z)-OH

• CAT Number: M044995
• CAS Number: 169287-77-8
• Molecular Formula: C24H29N7O8
• Molecular Weight: 543.54
• Purity: ≥95%
• Synonyms: (BOC-G(Z)-AEG-OH)
• Storage: -20°C
• IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[6-oxo-2-(phenylmethoxycarbonylamino)-3H-purin-9-yl]acetyl]amino]acetic acid
• InChI: InChI=1S/C24H29N7O8/c1-24(2,3)39-22(36)25-9-10-30(12-17(33)34)16(32)11-31-14-26-18-19(31)27-21(28-20(18)35)29-23(37)38-13-15-7-5-4-6-8-15/h4-8,14H,9-13H2,1-3H3,(H,25,36)(H,33,34)(H2,27,28,29,35,37)
• InChIKey: QPFRXGPXBKQVPU-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=NC2=C1NC(=NC2=O)NC(=O)OCC3=CC=CC=C3

BOC-PNA-G(Z)-OH(CAT: M044995) is a protected peptide nucleic acid (PNA) monomer incorporating guanine as the nucleobase. It features a tert-butoxycarbonyl (BOC) group protecting the amino terminus and a benzyloxycarbonyl (Z) group protecting the guanine exocyclic amine, with a free carboxylic acid at the C-terminus. This design ensures stability during solid-phase synthesis, enabling precise incorporation of guanine residues into custom PNA sequences. PNAs are synthetic DNA analogs with a peptide-like backbone, offering high binding affinity and specificity toward complementary nucleic acid targets. BOC-PNA-G(Z)-OH is widely used in antisense research, molecular diagnostics, and nucleic acid-based therapeutic development. Proper storage under inert, dry conditions is recommended.