Boc-N-PEG5-C2-NHS ester

• CAT Number: I016401
• CAS Number: 2055040-78-1
• Molecular Formula: C22H38N2O11
• Molecular Weight: 506.54
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C22H38N2O11/c1-22(2,3)34-21(28)23-7-9-30-11-13-32-15-17-33-16-14-31-12-10-29-8-6-20(27)35-24-18(25)4-5-19(24)26/h4-17H2,1-3H3,(H,23,28)
• InChIKey: FCVPAOUCTNORCY-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

Boc-N-PEG5-C2-NHS ester(CAT: I016401) is a heterobifunctional PEG linker featuring a Boc-protected amine, a PEG5 spacer with a C2 linker, and an N-hydroxysuccinimide (NHS) ester. The Boc group provides orthogonal protection, enabling selective deprotection and controlled incorporation into synthetic workflows. The PEG5 spacer imparts hydrophilicity, flexibility, and reduced steric hindrance, enhancing solubility and coupling efficiency. The activated NHS ester reacts readily with primary amines to form stable amide bonds. This reagent is widely applied in peptide modification, protein conjugation, and drug development, particularly in PEGylation strategies that improve biomolecule stability, solubility, and pharmacokinetic performance.