Boc-cis-3-hydroxy-L-proline

• CAT Number: R026096
• CAS Number: 186132-96-7
• Molecular Formula: C10H17NO5
• Molecular Weight: 231.25
• Purity: ≥95%
• Synonyms: (2S-cis)-3-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-Dimethylethyl) Ester;?(2S,3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic Acid; (2S,3R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic Acid
• Storage: Store at RT
• IUPAC Name: (2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-4-6(12)7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1
• InChIKey: JLDHXHPQMBNKMC-RQJHMYQMSA-N
• SMILES: CC(C)(C)OC(=O)N1CC[C@H]([C@H]1C(=O)O)O

Boc-cis-3-hydroxy-L-proline（Cat No.:R026096）is a protected derivative of the naturally occurring amino acid L-proline, featuring a hydroxyl group at the 3-position in the cis-configuration and a tert-butyloxycarbonyl (Boc) group protecting the amine. This compound is widely used in peptide synthesis, particularly for introducing conformationally constrained and hydrophilic residues into peptides and peptidomimetics. The Boc group ensures stability under mild conditions and is easily removed under acidic environments. Its rigid structure and stereochemistry make it valuable in medicinal chemistry for enhancing target specificity, metabolic stability, and structural diversity in bioactive molecules.