Boc-aminooxy-amide-PEG4-propargyl

• CAT Number: I016249
• CAS Number: 2253965-01-2
• Molecular Formula: C18H32N2O8
• Molecular Weight: 404.46
• Purity: ≥95%
• Synonyms: tert-butyl N-[2-oxo-2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylamino]ethoxy]carbamate
• InChI: InChI=1S/C18H32N2O8/c1-5-7-23-9-11-25-13-14-26-12-10-24-8-6-19-16(21)15-27-20-17(22)28-18(2,3)4/h1H,6-15H2,2-4H3,(H,19,21)(H,20,22)
• InChIKey: XDRDVAXJEVQKKC-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NOCC(=O)NCCOCCOCCOCCOCC#C

Boc-aminooxy-amide-PEG4-propargyl(CAT: I016249) is a multifunctional PEG-based linker designed for versatile bioconjugation. It features a Boc-protected aminooxy group, which can be selectively deprotected to enable oxime ligation with aldehydes and ketones, offering chemoselective conjugation under mild conditions. The propargyl moiety provides an alkyne handle for copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted click chemistry. The PEG4 spacer improves aqueous solubility, reduces steric hindrance, and enhances biocompatibility, ensuring efficient coupling in complex biological systems. This dual-functional linker is highly valuable for inhibitor synthesis, site-specific drug conjugation, and the development of targeted probes in cancer, immunology, and metabolic disease research.