For research use only. Not for therapeutic Use.
BN82002 hydrochloride (Cat No.: I045605) is a selective small-molecule inhibitor of cyclin-dependent kinase 1 (CDK1), a key regulator of cell cycle progression from G2 to M phase. By blocking CDK1 activity, BN82002 disrupts mitotic entry, leading to cell cycle arrest and apoptosis in proliferating cells. It has been studied in oncology research as a potential anticancer agent and as a probe for dissecting CDK-dependent signaling pathways. The hydrochloride salt form enhances solubility, making BN82002 hydrochloride suitable for biochemical and cellular investigations in cancer biology.
| CAS Number | 1049740-43-3 |
| Synonyms | 4-(dimethylamino)-2-methoxy-6-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]phenol;hydrochloride |
| Molecular Formula | C19H26ClN3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H25N3O4.ClH/c1-20(2)17-11-15(19(23)18(12-17)26-4)13-21(3)10-9-14-5-7-16(8-6-14)22(24)25;/h5-8,11-12,23H,9-10,13H2,1-4H3;1H |
| InChIKey | FGPZRTQNJSSCAQ-UHFFFAOYSA-N |
| SMILES | CN(C)C1=CC(=C(C(=C1)OC)O)CN(C)CCC2=CC=C(C=C2)[N+](=O)[O-].Cl |
| Reference | [1]. Brezak MC, et al. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res. 2004 May 1;64(9):3320-5. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
