For research use only. Not for therapeutic Use.
BMS-986299（Cat No.:I044414）is a toll-like receptor 8 (TLR8) agonist developed to stimulate innate immune responses, particularly in the context of cancer immunotherapy. By activating TLR8, BMS-986299 promotes the production of pro-inflammatory cytokines and enhances the maturation of dendritic cells and activation of T cells, fostering a robust antitumor immune environment. It is designed for intratumoral administration, aiming to modulate the tumor microenvironment and overcome immune suppression. BMS-986299 is under investigation in combination with checkpoint inhibitors and other immunotherapies, supporting research into novel strategies for enhancing antitumor immunity.
| CAS Number | 2242952-69-6 |
| Synonyms | N-[[4-amino-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethylacetamide |
| Molecular Formula | C18H19N7O |
| Purity | ≥95% |
| IUPAC Name | N-[[4-amino-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethylacetamide |
| InChI | InChI=1S/C18H19N7O/c1-3-25(10(2)26)9-15-22-16-12-5-4-11(13-6-7-20-24-13)8-14(12)21-18(19)17(16)23-15/h4-8H,3,9H2,1-2H3,(H2,19,21)(H,20,24)(H,22,23) |
| InChIKey | UHNRLQRZRNKOKU-UHFFFAOYSA-N |
| SMILES | CCN(CC1=NC2=C(N1)C(=NC3=C2C=CC(=C3)C4=CC=NN4)N)C(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
