BMS-986224（Cat No.:I044394）is a potent, selective, and orally bioavailable small-molecule agonist of the apelin receptor (APJ), a G protein-coupled receptor involved in cardiovascular homeostasis. By activating the apelin-APJ signaling pathway, BMS-986224 enhances cardiac contractility, promotes vasodilation, and supports vascular integrity without significantly increasing heart rate or oxygen demand. It is under investigation for the treatment of heart failure and related cardiovascular conditions. BMS-986224 demonstrates favorable pharmacokinetics and safety in preclinical models, positioning it as a promising candidate for novel therapies targeting cardiovascular dysfunction through apelin receptor modulation.