BMS-986176

• CAT Number: I044537
• CAS Number: 1815613-42-3
• Molecular Formula: C19H23F4N3O
• Molecular Weight: 385.40
• Purity: ≥95%
• Synonyms: (2S)-1-[2-(difluoromethyl)-6-[2-(difluoromethyl)pyridin-4-yl]pyridin-3-yl]oxy-2,4-dimethylpentan-2-amine
• InChI: InChI=1S/C19H23F4N3O/c1-11(2)9-19(3,24)10-27-15-5-4-13(26-16(15)18(22)23)12-6-7-25-14(8-12)17(20)21/h4-8,11,17-18H,9-10,24H2,1-3H3/t19-/m0/s1
• InChIKey: RKAHOQATMSONTM-IBGZPJMESA-N
• SMILES: CC(C)C[C@@](C)(COC1=C(N=C(C=C1)C2=CC(=NC=C2)C(F)F)C(F)F)N

BMS-986176（Cat No.:I044537）is an investigational small-molecule farnesoid X receptor (FXR) agonist developed to treat nonalcoholic steatohepatitis (NASH) and other liver diseases. FXR plays a crucial role in bile acid regulation, lipid metabolism, and inflammation control. By activating FXR, BMS-986176 aims to reduce hepatic fat accumulation and fibrosis. The compound has shown favorable pharmacokinetics and tolerability in early clinical trials, with potential benefits in improving liver histology. Its development highlights a promising therapeutic strategy for chronic liver conditions characterized by metabolic dysregulation and inflammation. Clinical evaluations are ongoing to assess its full efficacy and safety.