For research use only. Not for therapeutic Use.
BMS-986122 (Cat No.: I003236) is a small-molecule positive allosteric modulator (PAM) of the calcium-sensing receptor (CaSR). By binding to an allosteric site, it enhances receptor sensitivity to extracellular calcium without directly activating the receptor. This mechanism allows for more physiologically tuned regulation of calcium homeostasis. BMS-986122 has been explored in preclinical and early clinical research for conditions such as hypoparathyroidism, osteoporosis, and other mineral metabolism disorders. Its selective modulation offers therapeutic potential while reducing side effects associated with direct receptor agonists.
CAS Number | 313669-88-4 |
Synonyms | 2-(3-bromo-4-methoxyphenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine |
Molecular Formula | C16H15BrClNO3S2 |
Purity | ≥95% |
InChI | InChI=1S/C16H15BrClNO3S2/c1-22-15-7-2-11(10-14(15)17)16-19(8-9-23-16)24(20,21)13-5-3-12(18)4-6-13/h2-7,10,16H,8-9H2,1H3 |
InChIKey | PNGJPVDGZNPZHY-UHFFFAOYSA-N |
SMILES | COC1=C(C=C(C=C1)C2N(CCS2)S(=O)(=O)C3=CC=C(C=C3)Cl)Br |
Reference | [1]. Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. [2]. Kandasamy R, et al. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proc Natl Acad Sci U S A. 2021;118(16):e2000017118. [3]. Livingston KE, Alt A, Canals M, Traynor JR. Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Mol Pharmacol. 2018;93(2):157-167. |
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