BMS-963272

• CAT Number: I045331
• CAS Number: 1441057-15-3
• Molecular Formula: C24H21F6N5O2
• Molecular Weight: 525.45
• Purity: ≥95%
• Synonyms: (2S)-4-(4-methylphenyl)-5-(2H-tetrazol-5-yl)-2-[4-(4,4,4-trifluorobutoxy)phenyl]-2-(trifluoromethyl)-1,3-dihydropyridin-6-one
• InChI: InChI=1S/C24H21F6N5O2/c1-14-3-5-15(6-4-14)18-13-22(24(28,29)30,31-21(36)19(18)20-32-34-35-33-20)16-7-9-17(10-8-16)37-12-2-11-23(25,26)27/h3-10H,2,11-13H2,1H3,(H,31,36)(H,32,33,34,35)/t22-/m0/s1
• InChIKey: AEMPUAWUDAMJBV-QFIPXVFZSA-N
• SMILES: CC1=CC=C(C=C1)C2=C(C(=O)NC(C2)(C3=CC=C(C=C3)OCCCC(F)(F)F)C(F)(F)F)C4=NNN=N4

BMS-963272 (Cat No.: I045331) is an oral small-molecule antagonist of the P2X3 receptor, a ligand-gated ion channel involved in sensory neuron signaling, particularly in chronic cough and neuropathic pain. By selectively inhibiting P2X3, BMS-963272 reduces aberrant sensory nerve activation without significantly affecting taste perception, a common side effect of less selective P2X3 blockers. It has been investigated in clinical trials for refractory chronic cough and other hypersensory disorders. BMS-963272 offers a promising therapeutic approach for conditions involving hypersensitive peripheral sensory pathways.

Reference

[1]. Turdi H, et al. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem. 2021 Oct 14;64(19):14773-14792.
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