For research use only. Not for therapeutic Use.
BMS-962212（Cat No.:I018163）is a small-molecule, reversible inhibitor of Factor XIa (FXIa), a serine protease central to the intrinsic coagulation pathway. By selectively blocking FXIa activity, it reduces thrombin generation and clot formation without significantly affecting hemostasis, offering a safer anticoagulation profile compared to traditional agents. Preclinical and early clinical studies suggest BMS-962212 may be effective in preventing venous thromboembolism and other thrombotic disorders with lower bleeding risk. It serves as a valuable tool in cardiovascular and hematology research, advancing development of next-generation anticoagulant therapies.
| CAS Number | 1430114-34-3 |
| Synonyms | 4-[[(1S)-2-[(E)-3-[3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]prop-2-enoyl]-5-(4-methyl-2-oxopiperazin-1-yl)-3,4-dihydro-1H-isoquinoline-1-carbonyl]amino]benzoic acid |
| Molecular Formula | C32H28ClFN8O5 |
| Purity | ≥95% |
| IUPAC Name | 4-[[(1S)-2-[(E)-3-[3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]prop-2-enoyl]-5-(4-methyl-2-oxopiperazin-1-yl)-3,4-dihydro-1H-isoquinoline-1-carbonyl]amino]benzoic acid |
| InChI | InChI=1S/C32H28ClFN8O5/c1-39-15-16-40(28(44)17-39)25-4-2-3-22-21(25)13-14-41(30(22)31(45)36-20-7-5-19(6-8-20)32(46)47)27(43)12-9-23-26(42-18-35-37-38-42)11-10-24(33)29(23)34/h2-12,18,30H,13-17H2,1H3,(H,36,45)(H,46,47)/b12-9+/t30-/m0/s1 |
| InChIKey | WYFCZWSWFGJODV-MIANJLSGSA-N |
| SMILES | CN1CCN(C(=O)C1)C2=CC=CC3=C2CCN([C@@H]3C(=O)NC4=CC=C(C=C4)C(=O)O)C(=O)/C=C/C5=C(C=CC(=C5F)Cl)N6C=NN=N6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
