For research use only. Not for therapeutic Use.
BMS-817399（Cat No.:I023537）is a selective and potent antagonist of the prostaglandin D2 receptor 2 (DP2 or CRTH2), developed by Bristol-Myers Squibb for treating inflammatory and allergic conditions. By blocking DP2, BMS-817399 inhibits the recruitment and activation of Th2 cells, eosinophils, and basophils—key drivers in asthma, allergic rhinitis, and atopic dermatitis. Its high affinity and specificity offer targeted modulation of immune responses without broad immunosuppression. BMS-817399 has demonstrated promising anti-inflammatory effects in preclinical and early clinical studies, making it a potential therapeutic candidate for Th2-mediated inflammatory diseases.
| CAS Number | 1202400-18-7 |
| Synonyms | 1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea |
| Molecular Formula | C23H36ClN3O4 |
| Purity | ≥95% |
| IUPAC Name | 1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea |
| InChI | InChI=1S/C23H36ClN3O4/c1-15(2)18(26-20(29)25-13-22(5,6)30)19(28)27-12-11-23(31,21(3,4)14-27)16-7-9-17(24)10-8-16/h7-10,15,18,30-31H,11-14H2,1-6H3,(H2,25,26,29)/t18-,23+/m1/s1 |
| InChIKey | GTDPZONCGOCXOD-JPYJTQIMSA-N |
| SMILES | CC(C)[C@H](C(=O)N1CC[C@@](C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
