For research use only. Not for therapeutic Use.
BMS-684(CAT: I040606) is a highly selective small-molecule inhibitor of diacylglycerol kinase alpha (DGKα), exhibiting an IC₅₀ of 15 nM. It demonstrates exceptional specificity, showing over 100-fold selectivity against other type I DGK isoforms such as DGKβ and DGKγ, and does not inhibit any of the remaining seven DGK isozymes. BMS-684 is a valuable pharmacological tool for dissecting the unique biological functions of DGKα in pathways involving lipid signaling, T cell activation, cancer, and immune regulation. Its potent and isoform-specific inhibition supports mechanistic studies and therapeutic exploration targeting DGKα.
| CAS Number | 313552-29-3 |
| Synonyms | 4-(4-benzhydrylpiperazin-1-yl)-1-methyl-3-nitroquinolin-2-one |
| Molecular Formula | C27H26N4O3 |
| Purity | ≥95% |
| IUPAC Name | 4-(4-benzhydrylpiperazin-1-yl)-1-methyl-3-nitroquinolin-2-one |
| InChI | InChI=1S/C27H26N4O3/c1-28-23-15-9-8-14-22(23)25(26(27(28)32)31(33)34)30-18-16-29(17-19-30)24(20-10-4-2-5-11-20)21-12-6-3-7-13-21/h2-15,24H,16-19H2,1H3 |
| InChIKey | XIVOLEKHEMYRBO-UHFFFAOYSA-N |
| SMILES | CN1C2=CC=CC=C2C(=C(C1=O)[N+](=O)[O-])N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
