For research use only. Not for therapeutic Use.
BMS-1166-N-piperidine-COOH（Cat No.:I015298）is a potent small-molecule inhibitor derived from the BMS-1166 series, which targets the PD-1/PD-L1 immune checkpoint interaction. By blocking this pathway, the compound enhances T-cell activity and restores anti-tumor immune responses, making it a valuable tool in immuno-oncology research. The N-piperidine-COOH modification provides structural versatility for probing binding affinity and optimizing pharmacological properties. This molecule is primarily used in preclinical studies to investigate immune checkpoint blockade mechanisms, therapeutic design, and structure–activity relationships in cancer immunotherapy drug discovery.
| CAS Number | 2447066-00-2 |
| Synonyms | 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid |
| Molecular Formula | C37H35ClN2O6 |
| Purity | ≥95% |
| IUPAC Name | 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]piperidine-2-carboxylic acid |
| InChI | InChI=1S/C37H35ClN2O6/c1-24-28(8-5-9-30(24)27-11-12-33-36(18-27)44-15-14-43-33)23-46-35-19-34(45-22-26-7-4-6-25(16-26)20-39)29(17-31(35)38)21-40-13-3-2-10-32(40)37(41)42/h4-9,11-12,16-19,32H,2-3,10,13-15,21-23H2,1H3,(H,41,42) |
| InChIKey | RELGDHKISWTSBN-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)OCC5=CC(=CC=C5)C#N)CN6CCCCC6C(=O)O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
