Blasticidin S Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: R024204
  • CAS Number: 3513-03-9
  • PubChem Substance ID: 25078183
  • Molecular Formula: C₁₇H₂₆N₈O₅ · HCl
  • Molecular Weight: 458.90
  • Purity: ≥95%
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Blasticidin S hydrochloride (Cat No.: R024204) is a potent antibiotic and protein synthesis inhibitor derived from Streptomyces griseochromogenes. It targets both prokaryotic and eukaryotic ribosomes by interfering with peptide bond formation during translation. Widely used in molecular biology, it serves as a selective agent for the maintenance of plasmids or transgenes containing the bsd resistance gene. Its rapid action and broad-spectrum activity make it ideal for cell culture applications, including gene expression studies, stable cell line generation, and functional genomics in bacteria, yeast, and mammalian cells.


CAS Number 3513-03-9
Synonyms

Blasticidin S Monohydrochloride; (S)-4-[[3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-Hex-2-enopyranuronic Acid Monohydrochloride;

Molecular Formula C₁₇H₂₆N₈O₅ · HCl
Purity ≥95%
Target DNA Synthesis
Solubility Limited solubility
Appearance White solid
Storage Store at -20°C
IUPAC Name (2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride
InChI InChI=1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1
InChIKey YQXYQOXRCNEATG-ZAYJLJTISA-N
SMILES CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
Reference

<p>
Yamaguchi, I., et al. /Expression of the Blasticidin S Deaminase Gene (bsr) in Tobacco: Fungicide Tolerance and a New Selective Marker for Transgenic Plants./ <em>Molecular and General Genetics</em> 223.2 (1990): 332-34. <em>www.ncbi.gov</em>. Web. 7 Sept. 2012.</p>
<p>
/Blasticidin S Inhibits Translation by Trapping Deformed TRNA on the Ribosome./ PNAS 110.30 (2013): 12283-2288. Ncbi.nlm.nih.gov. Web. 4 Sept. 2014.</p>
<p>
Bento, Fernanda M. /Over Expression of the Selectable Marker Blasticidin S Deaminase Gene Is Toxic to Human Keratinocytes and Murine BALB/MK Cells./ BMC Biotechnology 4.29 (2004): 1-10. Springer.com. BioMed Central. Web. 4 Nov. 2014.</p>
<p>
Kimura, M. /Blasticidin S Deaminase Gene from Aspergillus Terreus (BSD): A New Drug Resistance Gene for Transfection of Mammalian Cells./ Biochemica Et Biophysica Acta. 1219.3 (1994): 653-59. Ncbi.nlm.nih.gov. Web. 4 Nov. 2014.</p>
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