Bisoctrizole

• CAT Number: I000215
• CAS Number: 103597-45-1
• Molecular Formula: C41H50N6O2
• Molecular Weight: 658.87
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 2-(benzotriazol-2-yl)-6-[[3-(benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
• InChI: 1S/C41H50N6O2/c1-38(2,3)24-40(7,8)28-20-26(36(48)34(22-28)46-42-30-15-11-12-16-31(30)43-46)19-27-21-29(41(9,10)25-39(4,5)6)23-35(37(27)49)47-44-32-17-13-14-18-33(32)45-47/h11-18,20-23,48-49H,19,24-25H2,1-10H3
• InChIKey: FQUNFJULCYSSOP-UHFFFAOYSA-N
• SMILES: CC(C)(C)CC(C)(C)C1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)CC4=C(C(=CC(=C4)C(C)(C)CC(C)(C)C)N5N=C6C=CC=CC6=N5)O

Bisoctrizole (Cat No.: I000215) is a broad-spectrum UV filter used in sunscreens to protect the skin from both UVA and UVB radiation. It is a hybrid organic-inorganic molecule that combines the benefits of physical and chemical sunscreens, offering photostability and minimal skin penetration. Bisoctrizole appears as a microfine particle, forming a protective layer on the skin’s surface without significant absorption. It is suitable for sensitive skin and commonly found in formulations with high sun protection factors (SPF). Bisoctrizole enhances sunscreen efficacy and stability.

Reference

[1]. Herzog B, et al. In vivo and in vitro assessment of UVA protection by sunscreen formulations containing either butyl methoxy dibenzoyl methane, methylene bis-benzotriazolyl tetramethylbutylphenol, or microfine ZnO. Int J Cosmet Sci. 2002 Jun;24(3):170-85.
[2]. Mavon A, et al. In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacol Physiol. 2007;20(1):10-20.
[3]. Ashby J, et al. Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S. Regul Toxicol Pharmacol. 2001 Dec;34(3):287-91.