Bisindolylmaleimide XI hydrochloride

• CAT Number: R057434
• CAS Number: 145333-02-4
• Molecular Formula: C28H29ClN4O2
• Molecular Weight: 489.01
• Purity: ≥95%
• Synonyms: 3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride
• InChI: InChI=1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H
• InChIKey: HSPRASOZRZDELU-UHFFFAOYSA-N
• SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl

Bisindolylmaleimide XI hydrochloride (Cat No.: R057434) is a synthetic small-molecule protein kinase C (PKC) inhibitor belonging to the bisindolylmaleimide class. It acts as an ATP-competitive antagonist, selectively inhibiting PKC isoforms involved in regulating cell proliferation, differentiation, and apoptosis. This compound has been used in studies of oncogenic signaling, cardiovascular function, and neurobiology, where PKC plays a central role. The hydrochloride salt enhances solubility and stability, making it suitable for experimental applications. It serves as a valuable tool in signal transduction and kinase-targeted research.

Reference

[1]. S E Wilkinson, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 ( Pt 2)(Pt 2):335-7.
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[2]. A M Birchall, et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.
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[3]. Roman Kholodenko, et al. Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism. Cell Res. 2007 Feb;17(2):151-62.
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