Bis-Tos-PEG7 (CAT: I016011) is a PEG-based linker commonly employed in the synthesis of PROTACs (PROteolysis TAgeting Chimeras), a promising class of molecules designed to selectively degrade target proteins within cells. This linker consists of two tosyl (Tos) protecting groups on one end and a polyethylene glycol (PEG) chain with seven units on the other end. It serves as a crucial component in constructing PROTAC molecules, enabling the specific binding of a target protein and an E3 ligase, ultimately leading to the degradation of the target protein through the ubiquitin-proteasome pathway.
| Catalog Number | I016011 |
| CAS Number | 69502-27-8 |
| Molecular Formula | C₂₈H₄₂O₁₂S₂ |
| Purity | 95% |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
