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Bis-Tos-PEG7

Bis-Tos-PEG7

  • CAT Number: I016011
  • CAS Number: 69502-27-8
  • Molecular Formula: C₂₈H₄₂O₁₂S₂
  • Molecular Weight: 634.76
  • Purity: ≥95%
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Bis-Tos-PEG7 (CAT: I016011) is a PEG-based linker commonly employed in the synthesis of PROTACs (PROteolysis TAgeting Chimeras), a promising class of molecules designed to selectively degrade target proteins within cells. This linker consists of two tosyl (Tos) protecting groups on one end and a polyethylene glycol (PEG) chain with seven units on the other end. It serves as a crucial component in constructing PROTAC molecules, enabling the specific binding of a target protein and an E3 ligase, ultimately leading to the degradation of the target protein through the ubiquitin-proteasome pathway.

Catalog Number I016011
CAS Number 69502-27-8
Molecular Formula

C₂₈H₄₂O₁₂S₂

Purity 95%
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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