Bis-sulfone-PEG4-DBCO

• CAT Number: I044567
• CAS Number: 1854034-70-0
• Molecular Formula: C54H59N3O12S2
• Molecular Weight: 1006.19
• Purity: ≥95%
• Synonyms: N-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]-4-[3-(4-methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanoyl]benzamide
• InChI: InChI=1S/C54H59N3O12S2/c1-40-11-21-48(22-12-40)70(62,63)38-47(39-71(64,65)49-23-13-41(2)14-24-49)53(60)44-17-19-45(20-18-44)54(61)56-28-30-67-32-34-69-36-35-68-33-31-66-29-26-51(58)55-27-25-52(59)57-37-46-9-4-3-7-42(46)15-16-43-8-5-6-10-50(43)57/h3-14,17-24,47H,25-39H2,1-2H3,(H,55,58)(H,56,61)
• InChIKey: ADIRLUISORIXON-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)CC(CS(=O)(=O)C2=CC=C(C=C2)C)C(=O)C3=CC=C(C=C3)C(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64

Bis-sulfone-PEG4-DBCO（Cat No.:I044567）is a multifunctional crosslinker featuring a dibenzocyclooctyne (DBCO) moiety, a PEG4 spacer, and a bis-sulfone group. The DBCO enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) with azide-containing biomolecules, ideal for bioorthogonal labeling in live-cell environments. The bis-sulfone group reacts with reduced disulfides in proteins, allowing site-specific crosslinking to thiols. The PEG4 linker enhances water solubility and spatial flexibility, reducing steric hindrance. Bis-sulfone-PEG4-DBCO is widely used in bioconjugation, protein crosslinking, and the development of antibody-drug conjugates (ADCs), enabling stable and selective modification in complex biological systems.