Bis-sulfone-PEG3-Azide

• CAT Number: I044569
• CAS Number: 1802908-01-5
• Molecular Formula: C33H40N4O9S2
• Molecular Weight: 700.82
• Purity: ≥95%
• Synonyms: N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-4-[3-(4-methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanoyl]benzamide
• InChI: InChI=1S/C33H40N4O9S2/c1-25-3-11-30(12-4-25)47(40,41)23-29(24-48(42,43)31-13-5-26(2)6-14-31)32(38)27-7-9-28(10-8-27)33(39)35-15-17-44-19-21-46-22-20-45-18-16-36-37-34/h3-14,29H,15-24H2,1-2H3,(H,35,39)
• InChIKey: IPFVUCCDSQHREM-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)CC(CS(=O)(=O)C2=CC=C(C=C2)C)C(=O)C3=CC=C(C=C3)C(=O)NCCOCCOCCOCCN=[N+]=[N-]

Bis-sulfone-PEG3-Azide（Cat No.:I044569）is a bifunctional crosslinker featuring a bis-sulfone group and an azide moiety linked via a PEG3 spacer. The bis-sulfone reacts selectively with reduced thiol groups, enabling site-specific conjugation to cysteine residues in proteins or peptides. The azide group allows bioorthogonal labeling through copper-catalyzed or strain-promoted azide-alkyne cycloaddition (click chemistry), facilitating modular attachment to alkyne-functionalized molecules. The PEG3 spacer improves aqueous solubility and reduces steric hindrance, enhancing biocompatibility. Bis-sulfone-PEG3-Azide is ideal for developing stable, multifunctional bioconjugates in chemical biology, drug delivery, and targeted therapeutic research applications.